Serum Vancomycin Concentration and Initial Dosage Regiment.
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Accession number;01A0256083
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| Title;Serum Vancomycin Concentration and Initial Dosage Regiment. |
| Author;
KOYAMA KAZUHIRO
(National Tokyo Medical Center, JPN)
OGASAWARA NOBUKO
(National Tokyo Medical Center, JPN)
AONO YOSHIHIRO
(National Tokyo Medical Center, JPN)
KAJIWARA HIROSHI
(National Tokyo Medical Center, JPN)
SEKIGUCHI HISANORI
(National Tokyo Medical Center, JPN)
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Journal Title;Japanese Journal of Hospital Pharmacy
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Journal Code:Y0888A
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ISSN:0389-9098
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VOL.27;NO.1;PAGE.24-28(2001)
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| Figure&Table&Reference;FIG.6, TBL.1, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We investigated the relationship between the serum vancomycin concentration and the initial dosage regimen. Furthermore, we evaluated the dose and dosage interval for the therapeutic level (trough <10.MU.g/mL, peak 25-40.MU.g/mL) and the toxic level (trough >15.MU.g/mL). The percentage of the concentration within the therapeutic level was 0% and the percentage over the toxic level was 71% regarding a vancomycin dose of 500mg every 6 hours. The percentage of the concentration within the therapeutic level was 0% and the percentage over a toxic level was 23% regarding a dose of 500mg every 12 hours. The percentage of the concentration within therapeutic level was 0% and the percentage over the toxic level was 33% regarding a dose of 1,000mg every 12 hours. The percentage of the concentration within the therapeutic level was 21% and the percentage over the toxic level was 11% regarding a dose of 1,000mg every 24 hours. The percentage of the concentration within the therapeutic level was 33% and the percentage over the toxic level was 10% regarding a dose of 1,500mg every 24 hours. As a result, a dose of 1,500mg every 24 hours was found to achieve the most appropriate therapeutic levels. On the other hand, a dose of 500mg every 6 hours showed a poor percentage of the concentration over the toxic level. (author abst.) |
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