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Accession number;01A0273750
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| Title;Presence of .ALPHA. 5 .BETA. 1 Integrin and Fibronectin in the Anterior Subcapsular Cataract. |
| Author;
YOSHINO MAMI
(Sch. of Med., Keio Univ.)
KUROSAKA DAIJIRO
(Sch. of Med., Keio Univ.)
OBAZAWA MINORU
(Sch. of Med., Keio Univ.)
TAKAYAMA FUSAO
(Kasumigaura National Hospital)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.105;NO.2;PAGE.83-87(2001)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.30 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: We investigated whether .ALPHA. 5 .BETA. 1 integrin and fibronectin were present in myofibroblast-like lens epithelial cells in anterior subcapsular cataract (ASC). Methods: Nine anterior capsule specimens were obtained from the patients during cataract surgery and frozen for cryostat sections. Six specimens were anterior capsule obtained from cataract with ASC. As a control, three specimens were obtained from cataract without ASC. Alpha-smooth muscle actin (.ALPHA.-SMA), .ALPHA. 5 .BETA. 1 integrin, and fibronectin were detected by immunohistochemical observation. Results: In all 6 specimens from patients with ASC, the lens epithelial cells around fibrosis tissue included myofibroblast-like lens epithelial cells which were positive for .ALPHA.-SMA. .ALPHA. 5 .BETA. 1 integrin was detected in these lens epithelial cells. Fibronectin was also detected around these myofibroblast-Iike lens epithelial cells. Three control specimens showed no immunoreactivity against .ALPHA.-SMA, .ALPHA. 5 .BETA. 1 integrin , or fibronectin. Conclusions: Alpha 5 .BETA. 1 integrin and fibronectin may play an important role in myodifferentiation of lens epithelial cells. (author abst.) |
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