Life Prognosis in Diabetic Patients with Retinopathy-Influence of macrovascular complications in heart, brain, and lower extremities.
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Accession number;01A0266258
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| Title;Life Prognosis in Diabetic Patients with Retinopathy-Influence of macrovascular complications in heart, brain, and lower extremities. |
| Author;
KIDA YASUO
(Daini Okamoto Gen. Hosp.)
KASHIWAGI ATSUNORI
(Shiga Univ. of Med. Sci.)
KIKKAWA RYUICHI
(Shiga Univ. of Med. Sci.)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.1;PAGE.23-29(2001)
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| Figure&Table&Reference;FIG.1, TBL.4, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To investigate the influence of macroangiopathy (MA) on the prognosis of diabetic subjects with retinopathy, we studied the prevalence of ischemic heart disease (IHD), cerebral infarction (CI), and arteriosclerosis obliterans (ASO) in 827 type 2 diabetic patients. Stages of retinopathy were defined as none (group N, n=495), simple (group S, n=216), and proliferative (group P, n=116). Complicated MA (MA score) was used as a marker of systemic atherosclerosis. Prevalence of IHD, CI, and ASO increased significantly with progressive retinopathy and the MA score was the highest in group P. Mortality rate (/1000 person year) of subjects in groups N, S, and P during the 4-year observation period was 5.6, 24.3, and 66.8. Cardiovascular and/or sudden death tended to be associated with proliferative retinopathy. Multivariate analysis suggests life prognosis was influenced independently by nephropathy, autonomic neuropathy, and MA score (especially ASO and IHD). Glycemic control, other atherogenic risk factor management, and noninvasive evaluation systemic MA are thus important in improving the prognosis in diabetic with proliferative retinopathy. (author abst.) |
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