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Accession number;01A0266262
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| Title;Pancreatic Histology of Case of Glutamic Acid Decarboxylase 65 Antibody-positive Noninsulin-requiring Diabetes Mellitus. |
| Author;
MARUYAMA TARO
(Zenkoku Shakai Hoken Kyokai Rengokai, Saitama Shakai Hoken Byoin)
KASUGA AKIRA
(Tokyo Denryoku Hosp.)
OZAWA YUKAKO
(Keio Univ.)
NAKAZATO TOMOCHIKA
(Zenkoku Shakai Hoken Kyokai Rengokai, Saitama Shakai Hoken Byoin)
IWASAKI RYOJI
(Zenkoku Shakai Hoken Kyokai Rengokai, Saitama Shakai Hoken Byoin)
SUZUKI YUTAKA
(Zenkoku Shakai Hoken Kyokai Rengokai, Saitama Shakai Hoken Byoin)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.1;PAGE.51-55(2001)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Glutamic acid decarboxylase 65 antibody (GADA)-positive patients initially diagnosed with non-insulin-dependent diabetes very often progress to insulin-dependent diabetes, suggesting patients have type 1 non-insulin-requiring diabetes according to the new classification of diabetes. Those with low GADA titer maintain good control without insulin for long years and seldom became insulin-requiring. It is thus very important to clarify whether such patients should be classified as type 1. We examined pancreatic islet pathology histologically in tissue from a diabetic patient with low GADA titer and pancreatic cancer who was not treated with insulin. Distinct insulitis was not found in any islet, and the size and number of insulin-stainin cells did not decrease. Further study is required to clarify whether diabetic patients with low GADA titer have a cellular autoimmunity to islet cells. (author abst.) |
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