Senile Changes in the Brain of a Masked Palm Civet, Paguma larvata.

Accession number;01A0400197
Title;Senile Changes in the Brain of a Masked Palm Civet, Paguma larvata.
Author; KAMIYA S (Nippon Veterinary And Animal Sci. Univ., Tokyo) HORI H (Nogeyama Zoological Gardens Of Yokohama, Yokohama, Jpn) YAMAMOTO Y (Nogeyama Zoological Gardens Of Yokohama, Yokohama, Jpn) TAKEDA H (Nogeyama Zoological Gardens Of Yokohama, Yokohama, Jpn) MIYAUCHI E (Nogeyama Zoological Gardens Of Yokohama, Yokohama, Jpn) TAKAISHI J (Nippon Veterinary And Animal Sci. Univ., Tokyo) YAMAGAMI T (Nippon Veterinary And Animal Sci. Univ., Tokyo) YAMANO S (Nippon Veterinary And Animal Sci. Univ., Tokyo)
Journal Title;Bulletin of Nippon Veterinary and Animal Science University
Journal Code:S0144B
ISSN:0373-8361
VOL.;NO.49;PAGE.1-4(2000)
Figure&Table&Reference;FIG.4, REF.13
Pub. Country;Japan
Language;English
Abstract;The brain of a 28-year-old male masked palm civet, Paguma larvata, without neurological signs was examined by light microscopy and histochemistry. The amyloid-.BETA.-protein immunostaining revealed that many senile plaques were disseminated throughout the cerebral cortex. A large number of polyglucosan bodies(PGB) were found throughout the brain, especially in the cerebellar cortex. PGB were round, basophilic and PAS-positive structures. They were situated free in the neuropil. Civet PGB were immunoreactive for a monoclonal antibody to human polyglucosan. A list of other changes includes amyloid angiopathy, an accumulation of lipofuscin, axonal spheroids, fibrous thickening of leptomeninges, and perivascular accumulation of lipid-laden cells. However, Alzheimer's neurofibrillary tangles could not be found. (author abst.)