The Effect of Revascularization by Percutaneous Transluminal Coronary Angioplasty on Oxygen Uptake Efficiency Slope.
|
Accession number;01A0305091
|
| Title;The Effect of Revascularization by Percutaneous Transluminal Coronary Angioplasty on Oxygen Uptake Efficiency Slope. |
| Author;
OHZEKI Y
(Toho Univ. Shcool Of Medicine)
|
Journal Title;Journal of the Medical Society of Toho University
|
Journal Code:G0654A
|
ISSN:0040-8670
|
|
VOL.48;NO.1;PAGE.3-12(2001)
|
| Figure&Table&Reference;FIG.3, TBL.5, REF.19 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The oxygen uptake efficiency slope (OUES) has been proposed as a novel index of cardiorespiratory functional reserve in patients with heart diseases. However, the physiological background of OUES remains unclear. The present study analyzed gas expired during exercise in patients with ischemic heart diseases, before and after revascularization by percutaneous transluminal coronary angioplasty (PTCA). Subsequently, the effect of myocardial ischemia on OUES was evaluated during exercise. In 6 patients who underwent successful revascularization, exercise-induced ischemic ST changes that had been observed before revascularization disappeared after revascularization, and the peak oxygen uptake (VO2 peak) and OUES were significantly higher after revascularization. However, the above parameters did not significantly change in 5 patients who underwent unsuccessful revascularization. Furthermore, physiologic pulmonary dead space to tidal volume ratio (VD/VT), arterial to end-tidal PCO2 difference [P (a-ET) CO2], minutes ventilation/oxygen uptake (VE/VO2), and the slope of minutes ventilation/carbon dioxide production ( VE/VCO2 slope) were significantly lower during exercise in patients who underwent successful revascularization. However, these parameters did not decrease during exercise in patients who underwent unsuccessful revascularization. These findings suggest that successful revascularization ameliorates myocardial ischemia during exercise, thus decreasing VD/VT after improvement of alveolar ventilation-perfusion mismatch, thereby increasing OUES. (author abst.) |
|
|
|
Related Articles;
|
|
