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The Use of Senna in Combination with a Bowel Preparation for Colonoscopy. The Comparative Study between Elderly and Younger Patients.

Accession number;01A0305094

Title;The Use of Senna in Combination with a Bowel Preparation for Colonoscopy. The Comparative Study between Elderly and Younger Patients.

Author; SAIDA YOSHIHISA (Toho Univ., Sch. of Med.) TAKASE MAKOTO (Toho Univ., Sch. of Med.) NAGAO JIRO (Toho Univ., Sch. of Med.) OKUMURA CHIDORI (Toho Univ., Sch. of Med.) KUSACHI SHIN'YA (Toho Univ., Sch. of Med.) KAJIWARA HIROHISA (Toho Univ., Sch. of Med.) SUMIYAMA YOSHINOBU (Toho Univ., Sch. of Med.) TAKUMA TETSUO (Tohokamatanibyoin) AOYAGI KEN (Tohokamatanibyoin)

Journal Title;Journal of the Medical Society of Toho University

Journal Code:G0654A

ISSN:0040-8670

VOL.48;NO.1;PAGE.29-33(2001)

Figure&Table&Reference;TBL.5, REF.12

Pub. Country;Japan

Language;Japanese

Abstract;To evaluate the efficacy of senna in a colonoscopy preparation combined with polyethylene glycol solution, a prospective randomized study was performed. Three hundred and seven patients who underwent colonoscopy from September 1998 to July 1999 were randomly divided into two groups. Group A (167 patients) took 1.0 g of senna the night before colonoscopy. Group B (140 patients) did not receive senna. The patients were further divided into 2 groups; below 65 years old (the younger group) and 65 and above (the elderly group). The two groups were then evaluated by rate of early defecation before colonoscopy (the rate of early defecation: Group A:Group B= 56%: 41%), the frequency of defecation before colonoscopy (Group A: Group B= 8.1:7.9), the time in bathroom (Group A:Group B= 5.2 hours:5.1 hours), the presence and degree of abdominal pain ( abdominal pain presence: Group A:Group B= 14%: 9 %, among the elderly; Group A:Group B= 21%: 3%), the patients' condition at the bowel preparation (the score of preparation; Group A:Group B= 2.2:2.1) and the time required for colonoscope to reach cecum (Group A: Group B=8.0 min.: 8.7 min., p=0.22). The findings suggest that senna taken the night before colonoscopy results in earlier defecation on the day of colonoscopic examination. However, senna did not improve bowel preparation. The elderly patients tended to experience greater abdominal pain after senna. Therefore, routine administration of senna in combination with polyethylene glycol appears undesirable. (author abst.)

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