Science Links Japan | Prediction of Residual Lung Function After Lung Surgery, and Examination of Blood Perfusion in the Pre- and Postoperative Lung Using Three-Dimensional SPECT.

Prediction of Residual Lung Function After Lung Surgery, and Examination of Blood Perfusion in the Pre- and Postoperative Lung Using Three-Dimensional SPECT.

Accession number;01A0305096

Title;Prediction of Residual Lung Function After Lung Surgery, and Examination of Blood Perfusion in the Pre- and Postoperative Lung Using Three-Dimensional SPECT.

Author; SHIMATANI SHINJI (Toho Univ., Sch. of Med.)

Journal Title;Journal of the Medical Society of Toho University

Journal Code:G0654A

ISSN:0040-8670

VOL.48;NO.1;PAGE.41-48(2001)

Figure&Table&Reference;FIG.2, TBL.1, REF.17

Pub. Country;Japan

Language;Japanese

Abstract;In order to predict postoperative pulmonary function after lung surgery, preoperative 99mTc-macroaggregated albumin (MAA) lung perfusion scans with single-photon emission computed tomography (SPECT) were performed. Spirometry was also performed before and 4-6 months after surgery in 40 patients. In addition, changes in blood perfusion in the pre- and postoperative lung were examined by postoperative lung perfusion scans in 18 of the 40 patients. We measured the three-dimensional (3-D) imaging volume of the operative and contralateral lungs using the volumes rendering method at blood perfusion thresholds of 20, 50 and 75%, utilizing 99mTc-MAA lung perfusion, and predicted pulmonary function by means of the measured volumes. We examined the correlation between predicted and the measured values of postoperative pulmonary function, forced vital capacity (FVC) and forced expiratory volume in one second (FEV1.0). The correlation between FEV1.0 predicted by SPECT (threshold 50%) and measured postoperative lung function resembled that between lung function predicted by the standard planar method and measured FEV1.0 in the lobectomy group. We then examined the ratios of both pre- and postoperative blood perfusion volumes obtained using 3-D imaging at lung perfusion threshold ranges of 10% each (PV20-29, PV30-39......) to pre- and postoperative total perfusion ( PV20-100). In the lobectomy group, the postoperative PV20-29/PV20-100 value was significantly higher for the operative side lung than the preoperative PV20-29/PV20-100 value, and the postoperative PV50-59, 60-69, 70-79, 80-89 and 90-100/PV20-100 values were significantly lower than the respective preoperative values. However, in the contralateral lung, the respective pre- and postoperative PV/PV20-100 values were almost identical.... (author abst.)

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