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Accession number;01A0457956
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| Title;The Role of Cytokines in the Pathogenesis of Diabetic Retinopathy. |
| Author;
OHARA KOZUE
(Tokyojikeikaiidai Gankagakukyoshitsu)
FUNATSU HIDEAKI
(Tokyojoidai Tonyobyose Ganka)
KITANO SHIGEHIKO
(Tokyojoidai Tonyobyose Ganka)
HORI SADAO
(Tokyojoidai Gankagakukyoshitsu)
YAMASHITA HIDETOSHI
(Yamagatadai I Gankagakukyoshitsu)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.105;NO.4;PAGE.213-217(2001)
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| Figure&Table&Reference;FIG.5, TBL.2, REF.28 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To investigate the role of cytokines and advanced glycation end products (AGEs) in the pathogenesis of diabetic retinopathy, we measured vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), tumor necrosis factor-.ALPHA. (TNF-.ALPHA.), transforming growth factor-.BETA.1 (TGF-.BETA.1), and pentosidine (an AGE) levels in aqueous, vitreous, and paired plasma obtained from diabetic patients. Results: The aqueous levels of VEGF and IL-6 were positively correlated with the grade of clinical severity of diabetic retinopathy (both VEGF and IL-6, p<0.001). Other cytokines and pentosidine levels were not significantly associated. The aqueous levels of VEGF and IL-6 were higher than the plasma levels (VEGF p=0.02, IL-6 p<0.001). Conclusion: Within the intraocular area VEGF and IL-6 are produced and participate in the pathogenesis of hyperpermeability of retinal vessels in preproliferative diabetic retinopathy. (author abst.) |
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