|
Accession number;01A0457957
|
| Title;Presynaptic Effects of Botulinum Toxin Type A on the Neuronally Evoked Response of Albino and Pigmented Rabbit Iris Sphincter and Dilator Muscles. |
| Author;
ISHIKAWA HITOSHI
(Kitasatodai I Gankagakukyoshitsu)
MITSUI YOSHIHISA
(Kitasatodai I Gankagakukyoshitsu)
YOSHITOMI TAKESHI
(Wakayamaken'idai Gankagakukyoshitsu)
MASHIMO KIMIYO
(Kitasatodai I Gankagakukyoshitsu)
AOKI SHIGERU
(Kitasatodai I Gankagakukyoshitsu)
MUKUNO KAZUO
(Kitasatodai I Gankagakukyoshitsu)
SHIMIZU KIMIYA
(Kitasatodai I Gankagakukyoshitsu)
|
Journal Title;Journal of Japanese Ophthalmological Society
|
Journal Code:Z0666A
|
ISSN:0029-0203
|
|
VOL.105;NO.4;PAGE.218-222(2001)
|
| Figure&Table&Reference;FIG.3, TBL.1, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To investigate the effects of botulinum toxin type A (botulinum A toxin) on the autonomic and other non-adrenergic, non-cholinergic nerve terminals. Methods: The effects of neurotoxin on twitch contractions evoked by electrical field stimulation (EFS) were studied in isolated rabbit iris sphincter and dilator muscles using isometric tension recording. Results: Botulinum A toxin (150nM) inhibited the fast cholinergic and slow substance P-ergic component of contraction evoked by EFS in the rabbit iris sphincter muscle without affecting the response to carbachol and substance P. Botulinum A toxin (150nM) did not affect the twitch contraction evoked by EFS in the rabbit iris dilator muscle. Conclusion: These data indicated that botulinum A toxin may inhibit not only the acetylcholine release in the cholinergic nerve terminals, but also substance P release from the trigeminal nerve terminals of the rabbit iris sphincter muscle. However, neurotoxin has little effect on the adrenergic nerve terminals of the rabbit iris dilator muscle. (author abst.) |
|
|
|
Related Articles;
|
|
