Establishment of the Measuring Tacrolimus Concentration in the Skin, and Application to Study on the Vehicle for Percutaneous Absorption.

Accession number;01A0587555
Title;Establishment of the Measuring Tacrolimus Concentration in the Skin, and Application to Study on the Vehicle for Percutaneous Absorption.
Author; ISHII SUMIO (Okayamadai I Byoin Yakuzaibu) ARAKI HIROAKI (Okayamadai I Byoin Yakuzaibu) MIYAKE SATORU (Okayamadai I Byoin Yakuzaibu) FUTAGAMI KOJIRO (Okayamadai I Byoin Yakuzaibu) FURUNO KATSUSHI (Okayamadai Shi Byoin Yakuzaibu) KUROSAKI YUJI (Okayama Univ., Graduate School of Natural Sci. and Technol., JPN) KAWASAKI HIROMU (Okayama Univ., Graduate School of Natural Sci. and Technol., JPN) GOMITA YUTAKA (Okayamadai I Byoin Yakuzaibu)
Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
Journal Code:Y0888A
ISSN:1346-342X
VOL.27;NO.2;PAGE.148-152(2001)
Figure&Table&Reference;FIG.3, REF.13
Pub. Country;Japan
Language;Japanese
Abstract;Tacrolimus (FK506) ointment has a good therapeutic effect on atopic dermatitis. The efficacy of Tacrolimus ointment, however, depends on the percutaneous adsorption of tacrolimus. To examine the influence of the ointment base on the percutaneous adsorption of tacrolimus, we performed a quantitative analysis of tacrolimus in the skin using an IMX (microparticle enzyme immunoassay) system. We prepared tacrolimus ointments using five kinds of ointment bases, i.e., Carbopol gel, White Petrolatum, Hydrophilic Ointment, Plastibase and Macrogol ointment. The concentration of tacrolimus in the rat abdominal skin were then determined 14 hours after the topical application of the different ointments to the rat skin by using the IMX system, and the effect of the various ointment bases was thus evaluated. As a result, the amount of tacrolimus in the skin measured 14 hours after topical application was as follows: Carbopol gel > White Petrolatum > Hydrophilic Ointment .IMAGE. Plastibase > Macrogol ointment. (author abst.)
Related Articles;
Loading...