Effects of a Low Pharmacological Oral Dose of Exogenous Melatonin, Administered 3 Hours before Habitual Bedtime, on Sleep in Normal Healthy Young Adults.
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Accession number;01A0282742
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| Title;Effects of a Low Pharmacological Oral Dose of Exogenous Melatonin, Administered 3 Hours before Habitual Bedtime, on Sleep in Normal Healthy Young Adults. |
| Author;
TSUTSUMI YASUMASA
(Kurume Univ., Fac. of Med.)
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Journal Title;Kyushu Neuropsychiatry
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Journal Code:Z0180B
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ISSN:0023-6144
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VOL.46;NO.3/4;PAGE.125-132(2000)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In the present study, 7 evening type healthy young adults recieved 3.0mg of melatonin (M) or a placebo (P) 15min, prior to going to bed. Overnight polysomnographic recordings (PSG) were thereafter begun at 21:00, 3 hours prior to their habitual bedtime, and were continued up until 05:00 the following morning. At the baseline (B), the PSG was recorded from 00:00 to 07:00. As a result, even tough the sleep latency was the shortest for M, no statistical defference was observed. The sleep efficiency tended to decrease more for P than for B, while it improved to the level of B after the administration of melatonin. The acrophase of the rectal temperature rhythm was significantly more advanced in M and P than in B. In addition, the REM latency tended to be shorter for M than for B. Based on the above findings, even though a low pharmacological oral dose of exogenous melatonin shows a mild improvement in the phase advanced sleep, we could not clearly demonstrate whether or not the observed effect was in fact a direct hypnotic effect. (author abst.) |
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