A Case of Bipolar Affective Disorder Who Showed a Severe Recurrence in the Involution Period.

Accession number;01A0282744
Title;A Case of Bipolar Affective Disorder Who Showed a Severe Recurrence in the Involution Period.
Author; HAYAKAWA MASAKI (Miyazaki Med. Coll.) ISHIDA YASUSHI (Miyazaki Med. Coll.) MITSUYAMA YOSHIO (Miyazaki Med. Coll.)
Journal Title;Kyushu Neuropsychiatry
Journal Code:Z0180B
ISSN:0023-6144
VOL.46;NO.3/4;PAGE.143-148(2000)
Figure&Table&Reference;FIG.4, REF.12
Pub. Country;Japan
Language;Japanese
Abstract;Bipolar disorders may well indicate a heterogeneous group of conditions with varying forms of biphasic mood dysregulation and a changing course across a patient's lifetime. Such disorders may also be modified by various factors including aging, genetic factors, a premorbid character, psychosocial factors, and somatic conditions. We herein report the case of a patient with a bipolar affective disorder who showed a severe recurrence in the involution period. The contributions of both aging and a stroke (silent cerebral infarction) to the etiology of this patient's disorder is also discussed. The patient, a 59-year-old man, first developed a bipolar affective disorder at 26 years of age, and thereafter, neither any depressive nor manic episodes recurred until he was 50 years of age. After the second depressive episode at 50 years of age, the frequency of depressive and manic episodes increased and the duration of each episode also became longer. Magnetic resonance image (MRI) findings demonstrated both frontal and temporal white-matter hyperintensities in the T2-weighted and FLAIR images bilaterally. During a depressive episode, the single photon emission computerized tomography (SPECT) findings demonstrated a decreased regional cerebral blood flow in the frontal and temporal lobes bilaterally. These organic brain lesions are thus suggested to be related to the severe recurrence observed in the involution period in this patient. (author abst.)
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