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Accession number;01A0282749
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| Title;Antiepileptic Effect of Dipotassium Clorazepate. |
| Author;
AMANO KOICHIRO
(National Sanatorium Kikuchi Hospital)
KATSURAGI SHOICHI
(National Sanatorium Kikuchi Hospital)
OGATA AKIRA
(Kumamoto Univ., Fac. of Educ.)
MIYAZAKI CHIHIRO
(National Sanatorium Kikuchi Hospital)
TAKAMATSU JUN'ICHI
(National Sanatorium Kikuchi Hospital)
DESHIMARU MOTONORI
(National Sanatorium Kikuchi Hospital)
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Journal Title;Kyushu Neuropsychiatry
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Journal Code:Z0180B
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ISSN:0023-6144
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VOL.46;NO.3/4;PAGE.177-181(2000)
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| Figure&Table&Reference;TBL.2, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To clarify the antiepileptic effects of dipotassium clorazepate (DC), we performed a clinical study on twenty-four patients with epileptic seizures refractory to conventional anticonvulsants. The patients were treated by adding DC to their normal regimen. Sixteen patients (66.7%) showed improvement in seizure frequency. The responses to DC did not significantly differ regarding the type of epilepsy, but DC did tend to be more effective in patients with localization-related epilepsy than in those with symptomatic generalized epilepsy. Among the various seizure types, the seizure frequency decreased in almost all patients with generalized tonic-clonic seizures, however, no patient with tonic seizures or atypical absence seizures were responsive to DC. No correlation between the antiepileptic efficacy and the serum levels was observed. Adverse effects were observed in eight patients (33.3%), however, none of these adverse effects were serious. The present study demonstrated that the use of DC may therefore be effective in the treatment of intractable epileptic seizures. (author abst.) |
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