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Accession number;01A0533957
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| Title;Effect of Caffeine on Microcirculation of Human Ocular Fundus. |
| Author;
OKUNO TAKASHI
(Osakaidai Gankagakukyoshitsu)
SUGIYAMA TETSUYA
(Osakaidai Gankagakukyoshitsu)
TOMINAGA MIKA
(Osakaidai Gankagakukyoshitsu)
KOJIMA SHOTA
(Osakaidai Gankagakukyoshitsu)
IKEDA TSUNEHIKO
(Osakaidai Gankagakukyoshitsu)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.105;NO.5;PAGE.308-313(2001)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.39 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To determine the effect of caffeine on the microcirculation in the human ocular fundus. Subjects and Methods: The microcirculation of the ocular fundus in 10 eyes of 10 healthy volunteers was studied using a laser speckle tissue circulation analyser. 100 mg of caffeine or placebo was given orally in a double-blind test. Square blur rate(SBR), a quantitative index of blood flow velocity, was measured in the temporal site of the optic nerve head(ONH) free of surface vessels and in the middle site of the choroid-retina between the ONH and the macula. Intraocular pressure(IOP), blood pressure(BP), pulse rate(PR), and central critical fusion frequency(CFF) were also measured. These parameters were measured before and for 2 hours after administration. The area under curve(AUC) of the SBR was calculated for each area. Ocular perfusion pressure(OPP) was also obtained from blood pressure and intraocular pressure. Results: The time-course change of SBR value showed much individual difference. Caffeine decreased the AUC of the SBR in the ONH as well as in the choroid-retina significantly. IOP, mean BP, PR, OPP and central CFF did not change significantly. Conclusions: These results suggest that caffeine may increase blood vessel resistance and decrease blood flow in the ONH and choroid-retina in humans. (author abst.) |
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