Effects of Pharmacists' Consultation on Serum Uric Acid Level in Outpatients with Hyperuricemia.

Accession number;01A0773154
Title;Effects of Pharmacists' Consultation on Serum Uric Acid Level in Outpatients with Hyperuricemia.
Author; SHINTOH M (Rokko Hospital) IWAKAWA S (Kobe Pharmaceutical Univ.) SHIMADA Y (Rokko Hospital) KONISHI K (Rokko Hospital)
Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
Journal Code:Y0888A
ISSN:1346-342X
VOL.27;NO.4;PAGE.363-368(2001)
Figure&Table&Reference;FIG.2, TBL.2, REF.18
Pub. Country;Japan
Language;English
Abstract;As part of the pharmaceutical guidance program using drug history notebooks for each patient and drug information leaflets, we gave pharmaceutical guidance to 37 outpatients with hyperuricemia chosen at random who were administered allopurinol or benzbromarone. The effects of pharmaceutical guidance on patient adherence were evaluated using changes in the serum uric acid level. The patients who were given conventional verbal explanations and shown descriptions on the drug bag were classified as the control group. Those who were given pharmaceutical guidance according to the pharmaceutical guidance program were classified as the intervention group. The baseline uric acid level and the levels 1 and 6 months after the start of pharmacist consultations were determined. Any patients who had changes in their drug prescriptions which affected their uric acid level during the investigation period were excluded. Sixteen patients in the control group and 17 in the intervention group were included in this study. There were no differences in the average value or variance of serum uric acid concentration at the baseline between the 2 groups. However, the average uric acid level decreased significantly 1 month after the start of consultations in the intervention group, while it did not changed in the control group. In patients showing baseline uric acid levels over 7 mg/dL, the uric acid levels showed a significant reduction in all patients in the intervention group, while the changes were not significant in the control group. These results showed that the pharmaceutical guidance performed by pharmacists enhanced the patients' medication compliance, thus resulting in an improvement of hyperuricemia. (author abst.)