Five Suspected Cases of Nonautoimmune Fulminant Type 1 Diabetes Mellitus.

Accession number;01A0530500
Title;Five Suspected Cases of Nonautoimmune Fulminant Type 1 Diabetes Mellitus.
Author; SHIMIZU IKKI (Ehimekenchuobyoin Naika) FUJII YASUHISA (Ehimekenchuobyoin Naika) KONOUE ETSUSHI (Nisseki Matsuyamasekijujibyoin Naika) KONDO SHIORI (Nisseki Matsuyamasekijujibyoin Naika) ITANI OSAMU (Ehimedai Rinshokensaigaku(tonyobyonaika)) TAKEDA HARUYO (Ehimedai Rinshokensaigaku(tonyobyonaika)) HASEGAWA MASAAKI (Ehimedai Rinshokensaigaku(tonyobyonaika)) ONUMA HIROSHI (Ehimedai Rinshokensaigaku(tonyobyonaika)) MAKINO HIDEICHI (Ehimedai Rinshokensaigaku(tonyobyonaika))
Journal Title;Journal of the Japan Diabetic Society
Journal Code:Z0279B
ISSN:0021-437X
VOL.44;NO.4;PAGE.315-322(2001)
Figure&Table&Reference;TBL.4, REF.31
Pub. Country;Japan
Language;Japanese
Abstract;Imagawa et al. defined rapid-onset type 1 diabetes with pancreatic exocrine dysfunction as nonautoimmune fulminant type 1 diabetes mellitus based on clinical and histological studies. We studied 5 patients suspected of nonautoimmune fulminant type 1 diabetes mellitus. They did not have antibodies against glutamic acid decarboxylase, IA-2, thyroid, gastric wall, adrenal cortex, or pituitary. Of the 5 patients, 4 were women, in whom 3, the onset of nonautoimmune fulminant type 1 diabetes mellitus was associated with pregnancy or delivery. Three of the 5 patients had HLA DRB 1*0405, DQB 1*0401, as haplotype susceptible to type 1 diabetes in Japanese. Another patient had both susceptible and protective haplotypes, but the other had none of these. We suggest nonautoimmune fulminant type 1 diabetes mellitus may be related to pregnancy or the HLA DRB 1*0405, DQB 1*0401 haplotype. (author abst.)
Related Articles;
Loading...