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Accession number;01A0530502
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| Title;Coagulation Factors in Type 2 Diabetes Mellitus: Association with Nephropathy. |
| Author;
KUBO KEIJI
(Kenritsuhiroshimabyoin Naibumpitsunaika)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.4;PAGE.329-334(2001)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To assess the relationship between diabetic nephropathy and coagulation factors, we divided 73 patients with type 2 diabetes mellitus into 3 groups-normoalbuminuria [normo] with urinary albumin excretion [UAE]<30 mg/day, microalbuminuria [micro] with [UAE] from 30-300, and macroalbuminuria [macro] with [UAE].GEQ.300. Their D dimer, prothrombin fragments F1+2 (F1+2), and fibrinogen were measured. D dimer was significantly higher in the micro group than in the normo group, and was significantly higher in the macro group than in the micro group. F1+2 was significantly higher in the micro and macro groups than in the normo group. Fibrinogen was signtficantly higher in the macro group than in the normo and micro groups. Thrombin activation may occur from the early stages of diabetic nephropathy, and may progress as nephropathy progresses. (author abst.) |
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