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Accession number;01A0649639
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| Title;A Case of Acute Cholestatic Hepatitis Associated with Fluvastatin Sodium. |
| Author;
WACHI K
(Toho Univ. School Of Medicine)
ISHII K
(Toho Univ. School Of Medicine)
IKEHARA T
(Toho Univ. School Of Medicine)
SHINOHARA M
(Toho Univ. School Of Medicine)
KAWAFUNE T
(Toho Univ. School Of Medicine)
SUMINO Y
(Toho Univ. School Of Medicine)
NONAKA H
(Toho Univ. School Of Medicine)
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Journal Title;Journal of the Medical Society of Toho University
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Journal Code:G0654A
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ISSN:0040-8670
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VOL.48;NO.2;PAGE.153-158(2001)
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| Figure&Table&Reference;FIG.2, REF.23 |
| Pub. Country;Japan |
| Language;English |
| Abstract;A 61-year old woman presented with clinical and laboratory signs of cholestatic and necrotic acute hepatitis. Symptoms had appeared 6 weeks after she began taking fluvastatin sodium (3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor), 20 mg/day for hypercholesterolemia. An evaluation by ultrasonography and liver biopsy confirmed the diagnosis of intrahepatic non-obstructing jaundice. Studies of viral markers and autoimmune factors excluded the possibilities of viral hepatitis and autoimmune hepatitis. Gas chromatography of the serum showed a high concentration of a metabolite of fluvastatin, suggesting a possible anomaly in her drug metabolism system. All liver function normalized eight weeks after the cessation of fluvastatin sodium. Fluvastatin should be considered as a potential cause of cholestatic hepatitis with a favorable clinical outcome after drug withdrawal. (author abst.) |
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