Alteration of Glucose Metabolism by Long Term High Fat and High Calorie Diet in Dogs.
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Accession number;01A0497990
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| Title;Alteration of Glucose Metabolism by Long Term High Fat and High Calorie Diet in Dogs. |
| Author;
HASEGAWA SHINOGU
(Nihonjuichikusandai Juinaikagakukyoshitsu)
HASUMI SUMIKO
(Teishinkai Nishiyamado Hosp.)
KATSUMORI KOZO
(Tokyo Women's Medical College, Diabetic Center)
KARIBE SACHIYO
(Tokyo Women's Medical College, Diabetic Center)
SAKO TOSHINORI
(Nihonjuichikusandai Juinaikagakukyoshitsu)
IWAMOTO YASUHIKO
(Tokyo Women's Medical College, Diabetic Center)
OMORI YASUE
(Saitamakensaisekai Kurihashi Hosp.)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.3;PAGE.197-202(2001)
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| Figure&Table&Reference;FIG.2, TBL.3, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We defined a high-fat, high-calorie diet (HFCD) as one doubling the minimum daily calorie intake by adding lard. Six beagles (3 males and 3 females) were fed an HFCD diet for 3 months. Before and after the diet, dogs were examined by intravenous glucose tolerance test (IVGTT) and euglycemic hyperinsulinemic clamp technique (GCT). After the HFCD, when insulin was infused at 2.5 and 5.0 mU/kg/min in the GCT, the glucose required to maintain the baseline decreased significantly. In the second IVGTT, the peak response and total secretion of plasma insulin increased significantly but, interestingly, no change was observed in either fasting plasma insulin or blood glucose half life. These results show that a 3-months HFCD induced an increased insulin response to glucose and wholebody insulin resistance, while fasting plasma insulin and glucose remained unchanged. Given that these findings represent the absence of hepatic insulin resistance, the HFCD appears primarily to impair peripheral insulin sensitivilty. (author abst.) |
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