Comparison of Insulin Assay Kits in Screening Insulinoma.
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Accession number;01A0497991
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| Title;Comparison of Insulin Assay Kits in Screening Insulinoma. |
| Author;
SHIMIZU TAKAO
(Osakafuseijinbyose Rinshokensaka)
SASAKUMA FUJIKO
(Osakafuseijinbyose Rinshokensaka)
HASEGAWA KYOICHI
(Itochushoji Osakakenkokanrishitsu)
SASAKI AKIRA
(Osakafuseijinbyose Chosabu)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.3;PAGE.203-207(2001)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.2 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We compared 5 insulin immunoassay kits in the diagnosis of insulinoma; 3 (E, S, and L) use polyclonal antibodies and 2 (R and EN) monoclonal antibodies. Interference by proinsulin was highest in kit L, followed by kits E and S, and low in kits R and EN. In noninsulinoma cases, IRI was similar among kits, although that assayed using kit EN was 5-15% lower than that by other kits. In insulinoma patients, IRI differed considerably among kits. IRI by kits R and EN were similar. That by kits E, S and L were 3.7, 3.5, and 5.1 times higher than those by kits R and EN. Positive Fajans' index was thus affected. Lowering the cutoff of Fajans' index did not have much effect. When kit R or EN is used, separate determination of proinsulin is strongly suggested when screening insulinoma. (author abst.) |
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