A Case of Glutamic Acid Decarboxylase 65 Antibody-and Insulin Autoantibody-positive Diabetes Mellitus Well Controlled without Insulin for 5 Years after Diabetic Ketoacidosis.
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Accession number;01A0497997
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| Title;A Case of Glutamic Acid Decarboxylase 65 Antibody-and Insulin Autoantibody-positive Diabetes Mellitus Well Controlled without Insulin for 5 Years after Diabetic Ketoacidosis. |
| Author;
IDE TOSHIMITSU
(Saitamashakaihokenbyoin Naika)
MARUYAMA TARO
(Saitamashakaihokenbyoin Naika)
KASUGA AKIRA
(Tokyodenryokubyoin Naika)
IWASAKI RYOJI
(Saitamashakaihokenbyoin Naika)
SUZUKI YUTAKA
(Saitamashakaihokenbyoin Naika)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.3;PAGE.241-245(2001)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We report a type 1 diabetic patient who developed diabetic ketoacidosis (DKA) whose plasma glucose has been well controlled by caloric restriction and exercise therapy alone for 5 years after DKA onset. A 38-year-old man developed thirst, polydipsia, and polyuria in November 1994. These symptoms worsened in January 1995 and body weight decreased 20 kg in 2 weeks. He was admitted to our hospital due to consciousness disturbance. Plasma glucose was 1,272 mg/dl and HbA1c and 13.2%, leading to the DKA diagnosis. Insulin therapy was started immediately and plasma glucose and HbA1c were well controlled within the normal range. Though GAD 65 antibody and insulin autoantibody were high, his diabetes improved to a noninsulindependent stage in April 1995 with increasing serum C-peptide. Now, 5 years after diabetes onset, his diabetes remains well controlled by caloric restriction and exercise therapy alone, without insulin, and serum C-peptide has been maintained. Swift, comprehensive insulin therapy and excellent plasma glucose control suppressed destruction of pancreatic .BETA.-cells, preventing progression to an insulin-dependent state over a long period. (author abst.) |
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