|
Accession number;01A0680948
|
| Title;Relationship between Serum .GAMMA.-glutamyl Transpeptidase Levels and the Risk of Diabetes Mellitus among Japanese-Americans. |
| Author;
NAKANISHI SHUHEI
(Hiroshimadai I Daininaika)
YAMASHITA YASUYO
(Hiroshimadai I Daininaika)
TAMURA TOMOKO
(Hiroshimadai I Daininaika)
OZAKI KAYO
(Hiroshimadai I Daininaika)
WATANABE HIROSHI
(Hiroshimadai I Daininaika)
FUJIKAWA RUMI
(Hiroshimadai I Daininaika)
ITO TATSUYA
(Serachuobyoin Naika)
OKUBO MASAMICHI
(Hiroshimadai I Daininaika)
EGUSA GENSHI
(Egusagenshikurinikku(hiroshimashi))
|
Journal Title;Journal of the Japan Diabetic Society
|
Journal Code:Z0279B
|
ISSN:0021-437X
|
|
VOL.44;NO.6;PAGE.475-480(2001)
|
| Figure&Table&Reference;FIG.1, TBL.4, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Serum .GAMMA.-glutamyl transpeptidase (.GAMMA.-GTP) has been postulated as a marker for insulin resistance, because of its association with type 2 diabetes mellitus, and obesity. We prospectively examined the relation between serum .GAMMA.-GTP levels and the incidence of diabetes mellitus and other risk factors among non-diabetic Japanese-Americans (419 men and 612 women) over a period of 7.4 years. The serum .GAMMA.-GTP level of subjects who developed diabetes was higher than that of subjects who did not develop diabetes. The serum .GAMMA.-GTP level was also correlated with insulin resistance, as expressed by homeostasis model assessment, among women, even after adjustments for age and body mass index had been made. All subjects were categorized in one of four serum .GAMMA.-GTP level categories. Women in higher serum .GAMMA.-GTP level categories exhibited a higher risk of developing diabetes. These results suggest that increases in serum .GAMMA.-GTP level, even within the normal range, are a potential marker of insulin resistance and a higher risk of developing diabetes among Japanese whose life-style has been rapidly westernized, especially in women. (author abst.) |
|
|
|
Related Articles;
|
