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Accession number;01A0680952
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| Title;A Case of Type 2 Diabetes Mellitus with Lewis Blood Group Phenotype (a-b-) with Elevated and Fluctuating Serum CA 19-9 Level. |
| Author;
NAKAGAWA YOSHINORI
(Saitamashakaihokenbyoin Naika)
MARUYAMA TARO
(Saitamashakaihokenbyoin Naika)
IWASAKI RYOJI
(Saitamashakaihokenbyoin Naika)
SUZUKI YUTAKA
(Saitamashakaihokenbyoin Naika)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.6;PAGE.501-504(2001)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Elevated serum CA 19-9 is often found in diabetic patients with poor blood glucose control. Subjects whose Lewis blood group phenotype is Le (a-b-), however, seldom show elevated serum CA 19-9. We describe a rare case of diabetes with elevated serum CA 19-9 fluctuated with blood glucose control. A 26-year-old man was admitted for malaise. Plasma glucose was 579 mg/dL and HbA1c 15.0%, suggesting diabetes. Serum CA 19-9 was 2780 IU/mL, but there was no evidence of malignancy. One month after achieving blood glucose control with insulin, serum CA 19-9 had fallen to 138 IU/mL. Six months later, he was readmitted worsening blood glucose due to a left renal abscess. Serum CA 19-9 increased to 177.7 IU/mL, but after drainage of the kidney, blood glucose control improved and serum CA 19-9 fell to normal. The Lewis blood group phenotype of erythrocytes was Le (a-b-), while that of saliva was Le (a-b+). This discordance suggests that adsorption of Lewis antigen in erythrocytes was inhibited by hyperglycemia. (author abst.) |
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