Human not Beef Insulin-Induced Liver Dysfunction in a Patient with Type 2 Diabetes Mellitus.
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Accession number;01A0680953
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| Title;Human not Beef Insulin-Induced Liver Dysfunction in a Patient with Type 2 Diabetes Mellitus. |
| Author;
MONDEN TSUYOSHI
(Gunmadai I Dai1naika)
KAWAMURA YUKIKO
(Gunmadai I Dai1naika)
IMAMURA MAKOTO
(Gunmadai I Dai1naika)
OGIWARA TAKAYUKI
(Gunmadai I Dai1naika)
SHIMIZU HIROYUKI
(Gunmadai I Dai1naika)
MORI MASATOMO
(Gunmadai I Dai1naika)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.6;PAGE.505-508(2001)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 51-year old man with type 2 diabetes mellitus was admitted for insulin treatment. One year before admission, he had Penfill 30 R therapy at another hospital due to poor glycemic control. Liver dysfunction occurred and insulin treatment was discontinued. On admission, his liver function was normal, with no evidence of type B or C hepatitis. HbA1c was 10.8%, and urinary CPR was 8.8 .MU.g/day. Nine days after Humacart N administration, his aminotransferase became elevated (GOT 72 IU/l, GPT 154 IU/l). We tried rapid insulin Humulin R, but liver function did not improve. After liver function recovered, NPH Iszilin, made from beef pancreas, was started. His glycemic control improved rapidly without liver dysfunction. Insulin antibody was within normal limit and lymphocyte stimulation tests for Humacart N and Humulin R were negative, although his eosinophil level increased slightly to 6%. We report this case because animal insulin is considered to be a possible therapy for liver dysfunction in human insulin treatment. (author abst.) |
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