Inhibition of Cyclooxygenase Pathway Metabolite Release from Guinea Pig and Human Lung Fragments by Pemirolast Potassium.
|
Accession number;01A0695922
|
| Title;Inhibition of Cyclooxygenase Pathway Metabolite Release from Guinea Pig and Human Lung Fragments by Pemirolast Potassium. |
| Author;
KAWASHIMA T
(Toho Univ. School Of Medicine, Chiba)
|
Journal Title;Journal of the Medical Society of Toho University
|
Journal Code:G0654A
|
ISSN:0040-8670
|
|
VOL.48;NO.3;PAGE.225-232(2001)
|
| Figure&Table&Reference;FIG.7, TBL.1, REF.24 |
| Pub. Country;Japan |
| Language;English |
| Abstract;This study was aimed at determining whether pemirolast potassium (pemirolast), an antiallergic drug, could affect the release of cyclooxygenase pathway metabolites from the lung fragments of guinea pigs and humans. Pemirolast concentration-dependently inhibited antigen-induced prostaglandin D2 (PGD2) and thromboxane A2 (TXA2) releases from lung fragments of guinea pigs passively sensitized with anti-ovalbumin serum of guinea pigs at a concentration of 1*10-5 M or higher. In contrast, pemirolast did not inhibit the release of prostaglandin I2 (PGI2). Pemirolast also concentration-dependently inhibited antigen-induced PGD2 and TXA2 releases from human lung fragments passively sensitized with anti-mite serum at a concentration of 1*10-6 M or higher. Pemirolast had no inhibitory effect on PGI2 release in human lung fragments, whereas indomethacin, at a concentration of 1*10-6 M, inhibited antigen-induced PGD2, TXA2, and PGI2 releases from both guinea pig and human lung fragments. These results indicate that pemirolast inhibits the release of cyclooxygenase pathway metabolites by a mechanism different to that of indomethacin. (author abst.) |
|
|
|
Related Articles;
|
|
