Anti-Mouse TNF-.ALPHA. Monoclonal Antibody and Pentoxifylline Attenuate Experimental Cerulein-Induced Pancreatitis in C57BL/6NJ Mice.
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Accession number;01A0695923
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| Title;Anti-Mouse TNF-.ALPHA. Monoclonal Antibody and Pentoxifylline Attenuate Experimental Cerulein-Induced Pancreatitis in C57BL/6NJ Mice. |
| Author;
HONG T
(Toho Univ. School Of Medicine, Tokyo)
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Journal Title;Journal of the Medical Society of Toho University
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Journal Code:G0654A
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ISSN:0040-8670
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VOL.48;NO.3;PAGE.233-243(2001)
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| Figure&Table&Reference;FIG.9, REF.20 |
| Pub. Country;Japan |
| Language;English |
| Abstract;This study was undertaken to determine the therapeutic efficacies of TNF-.ALPHA. monoclonal antibody (mAb) and pentoxifylline on cerulein-induced pancreatitis in C57BL/6NJ mice and to illuminate the role of cytokine in the pathogenesis of this disease by treatment with either TNF-.ALPHA. mAb or pentoxifylline before or after cerulein-induced pancreatitis. Administration of 25.MU.g/kg TNF-.ALPHA. mAb either before or after cerulein-induced pancreatitis decreased pancreatic wet weight, serum amylase, IL-1.BETA., IL-6 and pancreatic edema, necrosis and inflammatory cell infiltration. Administration of pentoxifylline at doses of 100mg/kg and 50mg/kg before or after the induction of panceatitis significantly decreased pancreatic wet weight, serum amylase, IL-1.BETA. and IL-6. Administration of 25mg/kg pentoxifylline had significant effects before, but not after the induction of pancreatitis. Moreover, the effectiveness of pentoxifylline in attenuating IL-1.BETA. and IL-6 after cerulein-induced pancreatitis was similar to that with twice the dosage of pentoxifylline administered before induction. In conclusion, the proinflammatory cytokines IL-1.BETA. and IL-6 elevated during experimental acute pancreatitis and these cytokines correlate well with the damage to the pancreas. The use of TNF-.ALPHA. or pentoxifylline before or soon after cerulein-induced pancreatitis significantly attenuated increases in IL-1.BETA. and IL-6, and is associated with decreased severity of pancreatitis. (author abst.) |
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