Common Carotid Arterial Wall Thickness and Diurnal Blood Pressure Changes in Patients with Type 2 Diabetes Mellitus.
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Accession number;01A0793352
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| Title;Common Carotid Arterial Wall Thickness and Diurnal Blood Pressure Changes in Patients with Type 2 Diabetes Mellitus. |
| Author;
KAWAMOTO RYUICHI
(Nomuramachinomurabyoin Naika)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.7;PAGE.541-547(2001)
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| Figure&Table&Reference;TBL.4, REF.23 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To study the relation between diurnal blood pressure variations and common carotid atherosclerosis, we performed both 24-hour ambulatory blood pressure monitoring (ABPM) and common carotid arterial imaging by ultrasonography in 60 type 2 diabetic patients. We further classified the patients into dippers (nocturnal reduction of systolic blood pressure (SBP) by .GEQ. 10% to < 20% of daytime SBP; n = 13), non-dippers (reduction by .GEQ. 0% to < 10%; n = 35), and inverted-dippers (reduction by < 0%; n = 12). There were no differences in background factors, such as age, sex, body mass index, duration of diabetes mellitus, Brinkman index, blood lipids, uric acid and HbA1c levels, daily urinary C-peptide reactivity, CV % of the R-R interval, and daytime BP. The carotid arterial wall thickness was significantly higher in the inverted-dippers group than in the dippers or non-dippers group (p < 0.05). A logistic regression analysis using the carotid arterial wall thickness (defined as hypertrophic if greater than 1.0mm) as the object variable and various risk factors including ABPM parameters, as the explanatory variables revealed that a pattern of a nighttime fall in SBP (dipper, non-dipper or inverted dipper) or nighttime SBP were significant independent contributing factors. These results suggest that nocturnal SBP elevation is an important risk factor for the thickening of the carotid arterial walls. (author abst.) |
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