A Rare Case of Multiple Sclerosis Associated with Type 1 Diabetes Mellitus with a History of Basedow Disease.
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Accession number;01A0718620
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| Title;A Rare Case of Multiple Sclerosis Associated with Type 1 Diabetes Mellitus with a History of Basedow Disease. |
| Author;
MOGAMI YASUO
(Tohodai Naikagakudaiichikoza)
TOJO YASUSHI
(Tohodai Naikagakudaiichikoza)
ATSUTA MITSUKA
(Tohodai Naikagakudaiichikoza)
KUBOKI KOJI
(Tohodai Naikagakudaiichikoza)
TADA HISAYA
(Tohodai Naikagakudaiichikoza)
KAMEYAMA MASAAKI
(Tohodai Naikagakudaiichikoza)
INOKUCHI TOSHIKI
(Tohodai Naikagakudaiichikoza)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.5;PAGE.399-403(2001)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 35-year-old woman with a 1-year history of type 1 diabetes mellitus(DM) was admitted in December 1997 with dysphagia, deteriorated vision, diplopia, and dyspnea. At age 14 years, Basedow disease had been successfully treated with radioiodine. She was diagnosed as having type 1 DM at age 34, being positive for anti-GAD antibody and (ICA). Neurological examination on admission revealed left oculomotor nerve palsy, optic neuritis, and bulbar palsy. Magnetic resonace imaging(MRI) showed multiple high signal intensity (T2) lesions in the midbrain, pons, and medulla oblongata. IgG and myelin basic protein were positive in cerebrospinal fluid, heading to a diagnosis of multiple sclerosis(MS). After admission, she was immediately treated with steroid pulse therapy and her glycemia strictly controlled with continuous subcutaneous insulin infusion, which simultaneously improved both hyperglycemia and anti-GAD antibody titer, in addition to MS. In August 1998, the patient was readmitted with relapsing MS, together with marked elevations of plasma glucose and anti-GAD antibody, all improved with the same treatment as previously, suggesting that autoimmunity and hyperglycemia play important roles in the onset or exacerbation of MS associated with type 1 DM. (author abst.) |
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