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Accession number;01A0718621
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| Title;A Diabetic Patient with Glucagonoma Syndrome Diagnosed 20 years after Appearance of Nonspecific Skin Lesions and Hyperglycemia. |
| Author;
TAKEDA MASANOBU
(Tokyojoidai Tonyobyose Dai3naika)
SUGANUMA SHIN'YA
(Tokyojoidai Tonyobyose Dai3naika)
SUZUKI NATSUKO
(Tokyojoidai Tonyobyose Dai3naika)
BABASONO TETSUYA
(Tokyojoidai Tonyobyose Dai3naika)
IWASAKI NAOKO
(Tokyojoidai Tonyobyose Dai3naika)
SHINJO TAKAMICHI
(Tokyojoidai Tonyobyose Dai3naika)
TAKASAKI KEN
(Tokyojoidai Shokakibyose Geka)
IWAMOTO YASUHIKO
(Tokyojoidai Tonyobyose Dai3naika)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.44;NO.5;PAGE.405-409(2001)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 68-year-old man was referred to our hospital with diabetes mellitus, exanthema of the legs, and weight loss. He had been diagnosed with diabetes when 46 years old and diet therapy was initiated, but glucose control was poor. He had suffered from intractable exanthema of the lower legs since age 48. Insulin therapy was started when he was 59, after which his exanthema worsened. Close examination on admission showed hypoproteinemia, marked anemia, and a calcified pancreatic tumor in computed tomography(CT) scanning. Plasma pancreatic glucagon (IRG) was 2360pg/ml. After subtotal pancreatectomy with total splenectomy, skin lesions and high IRG disappeared. The tumor was diaguosed immunohistopathologically as glucagonoma. Exanthema in this patient was inconsistent with necrolytic migratory erythema(NME), a pathoguomonic symptom of glucagonoma syndrome. In summary, glucagonoma was found 20 years after diabetes was diagnosed, indicating the difficulty of making a differential diagnosis of skin lesions. (author abst.) |
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