Distribution of Ganglion Cells and Protein Gene Product 9.5 Immunoreactivity in the Developing and Aging Rat Tongue.
|
Accession number;01A0901046
|
| Title;Distribution of Ganglion Cells and Protein Gene Product 9.5 Immunoreactivity in the Developing and Aging Rat Tongue. |
| Author;
SHEN C L
(National Cheng Kung Univ., Medical Coll., Tainan City, Twn)
CHEN S T
(National Cheng Kung Univ., Medical Coll., Tainan City, Twn)
|
Journal Title;Biomed Res
|
Journal Code:Z0236B
|
ISSN:0388-6107
|
|
VOL.22;NO.2;PAGE.67-76(2001)
|
| Figure&Table&Reference;FIG.4, TBL.1, REF.29 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Previous studies have indicated that several neuronal substances are expressed in the tongues of various species. The majority of these studies have concentrated on the taste buds of adult tissues, while few have explored neuronal populations, especially in developing and aging tissues. This study utilizes general histological and immunocytochemical techniques to investigate the distribution of ganglion cells during perinatal, mature, and aging stages. Experimental results indicate that there are at least two types of ganglion cells in the tongue: small neurons that are diffusely distributed in the lamina propria and the perivascular space of the arteries, and medium to large neurons that are located around the muscle bundles and glands, aggregating to form a ganglion. Three ganglia always appear in the rat tongue: in the basal core of the circumvallate papillae, in the ventral surface of the body of the tongue near the lingual vessels, and in the lateral side of the base of the root of the tongue. The ganglion cells and developing papillae first appear on the twelfth day of gestation (E12) as revealed by hematoxylin and eosin staining, whereas the immunoreactivity of protein gene product 9.5 (PGP 9.5), a neurochemical marker, is present at E13. After birth, the staining intensity of PGP 9.5-immunoreactive (IR) cells and nerve bundles increases in diffuse ganglion cells, taste buds, core of the papillae, and remote ganglia. The number of PGP 9.5-IR neurons, however, decreases with aging. Two-year old rats show half as many as PGP 9.5 neurons as compared to young adults. This early and long-lasting expression of PGP 9.5 and its downregulation with age suggest that this protein is not only a useful marker in identifying neuronal distribution but may be involved in taste or other functions. (author abst.) |
|
|
|
Related Articles;
|
|
