Inhibitory Effect of Cerebellin on Rat Thyroid Gland.
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Accession number;01A0901050
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| Title;Inhibitory Effect of Cerebellin on Rat Thyroid Gland. |
| Author;
MALENDOWICZ L K
(School Medicine, Poznan, Pol)
MACCHI C
(Univ. Padua, Padua, Ita)
NUSSDORFER G G
(Univ. Padua, Padua, Ita)
NOWAK K W
(Poznan Univ. Agriculture, Poznan, Pol)
ZIOLKOWSKA A
(School Medicine, Poznan, Pol)
TREJTER M
(School Medicine, Poznan, Pol)
GINDA W J
(School Medicine, Poznan, Pol)
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Journal Title;Biomed Res
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Journal Code:Z0236B
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ISSN:0388-6107
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VOL.22;NO.2;PAGE.99-101(2001)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.11 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Cerebellin (CER) is a 16-amino acid peptide originally isolated from rat cerebellum, which has been recently reported to stimulate adrenal-gland secretion. We have investigated the effects of the prolonged administration of CER and its analogue [Der-Ser1]-CER (CERA) (15nmol/kg day for 6 days) on the growth and function of rat thyroid gland. CER and CERA markedly increased the weight of thyroid gland. Thyroid follicles contained large amounts of colloid and their epithelial cells were shorter than those of control rats. Accordingly, morphometry showed that epithelium/colloid ratio was strikingly lowered. These changes strongly suggest that CER and CERA exert an inhibitory effect on rat thyroid-gland secretion, downstream to colloid synthesis. However, serum concentrations of thyroid-stimulating hormone and thyroid hormones were not significantly altered by CER and CERA treatment, thereby making it likely that the inhibitory effect is only partial. (author abst.) |
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