Melatonin decreases glucocorticoid blood concentration in the rat and palm squirrel, acting directly on the adrenal gland.
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Accession number;01A0901053
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| Title;Melatonin decreases glucocorticoid blood concentration in the rat and palm squirrel, acting directly on the adrenal gland. |
| Author;
APPA RAO N V
(St. Xavier Coll., Ranchi, Ind)
RAZA B
(Univ. Ranchi, Ranchi, Ind)
PRASAD J K
(Univ. Ranchi, Ranchi, Ind)
RAZI S S
(Univ. Ranchi, Ranchi, Ind)
GOTTARDO L
(Univ. Padua, Padua, Ita)
AHMAD M F
(Univ. Ranchi, Ranchi, Ind)
NUSSDORFER G G
(Univ. Padua, Padua, Ita)
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Journal Title;Biomed Res
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Journal Code:Z0236B
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ISSN:0388-6107
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VOL.22;NO.2;PAGE.115-117(2001)
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| Figure&Table&Reference;FIG.2, REF.17 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We have investigated the effect of the prolonged administration of melatonin on the plasma concentration of glucocorticoids in rats and palm squirrels, whose hypothalamo-pituitary-adrenal axis and renin-angiotensin system were suppressed by the simultaneous administration of dexamethasone and captopril. Dexamethasone and captopril administration for two weeks markedly lowered the blood level of corticosterone in rats and cortisol in palm squirrels. The injection of melatonin during the second week of treatment caused a further significant lowering in the glucocorticoid plasma concentration. These findings suggest that melatonin exerts a sizeable glucocorticoid antisecretagogue effect in rats and squirrels, acting directly on the adrenal glands. (author abst.) |
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