Science Links Japan | Sex hormone reduction on osteopetrotic (op/op) mice promotes osteoclast differentiation and can substitute for lack of macrophage colony-stimulating factor.

Sex hormone reduction on osteopetrotic (op/op) mice promotes osteoclast differentiation and can substitute for lack of macrophage colony-stimulating factor.

Accession number;01A0901054

Title;Sex hormone reduction on osteopetrotic (op/op) mice promotes osteoclast differentiation and can substitute for lack of macrophage colony-stimulating factor.

Author; KAWATA T (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) FUJITA T (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) KAKU M (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) MATSUKI A (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) TOKIMASA C (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) KOHNO S (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) TSUTSUI K (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn) TANNE K (Hiroshima Univ. Fac. Dentistry, Hiroshima, Jpn)

Journal Title;Biomed Res

Journal Code:Z0236B

ISSN:0388-6107

VOL.22;NO.2;PAGE.119-123(2001)

Figure&Table&Reference;FIG.2, TBL.1, REF.18

Pub. Country;Japan

Language;English

Abstract;We examined changes in the appearance of osteoclasts in the femora of ovariectomy (OVX) or orchiectomy (ORX) op/op mice given injections of estrogen (17.BETA.-oestradiol) or non-aromatizable androgen (5.ALPHA.-dihydrotestosterone). The number of osteoclasts on the trabecular bone surface of the OVX and ORX op/op mice significantly increased in number to seven or eight times as compared with those in sham-operated op/op mice. The increased number of osteoclasts in the OVX or ORX mice were substantially suppressed by administration of oestrogen and dihydrotestosterone. Furthermore, tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts increased in number about four times in 100-week-old females and males, compared with 16-week-old sham-operated groups. The increase of osteoclasts in the 100-week-old female and male mice were substantially suppressed by oestrogen and dihydrotestosterone. These results demonstrated that a sex hormone reduction due to OVX or ORX induces prominent recruitment of osteoclasts in the op/op mice. Moreover, we demonstrated that osteoclasts were substantially suppressed by sex hormones in OVX or ORX op/op mice. (author abst.)

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