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Accession number;01A0228944
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| Title;Cooperative Triple-Helix Formation of Metal Cheleting Group-Oligonucleotide Conjugates. |
| Author;
IHARA TOSHIHIRO
(Kumamoto Univ., Fac. of Eng.)
TAKEDA YUKA
(Kumamoto Univ., Fac. of Eng.)
SUEDA SHINJI
(Kyushu Univ., Grad. Sch.)
TAKAGI MAKOTO
(Kyushu Univ., Grad. Sch.)
JO AKINORI
(Kumamoto Univ., Fac. of Eng.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.15th;NO.;PAGE.4-5(2000)
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| Figure&Table&Reference;FIG.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We synthesized two DNA conjugate which consist of an oligopyrimidine for binding, and a glutamic acid and imminodiacetic acid for Cu2+-assisted dimerization. Cupric ion promotes the formation of the triple-stranded complexes through gathering two conjugates to make the symmetric dimmer on the dyad double-stranded sequence. The cooperativity, .OMEGA., was estimated to be ca. 165 at 298 K. (author abst.) |
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