Science Links Japan | Design of modified oligonucleotides for the photo-regulation of DNA-function (16) Investigation on the mechanism of photo-regulation of DNA duplex formation and dissociation by the modified DNA carrying an azobenzene.

Design of modified oligonucleotides for the photo-regulation of DNA-function (16) Investigation on the mechanism of photo-regulation of DNA duplex formation and dissociation by the modified DNA carrying an azobenzene.

Accession number;01A0228948

Title;Design of modified oligonucleotides for the photo-regulation of DNA-function (16) Investigation on the mechanism of photo-regulation of DNA duplex formation and dissociation by the modified DNA carrying an azobenzene.

Author; ASANUMA HIROYUKI (Univ. of Tokyo, RCAST Res. Center for Adv. Sci. and Technol.) KAWAI GOTA (Chiba Inst. of Technol., Fac. of Eng.) SAKAMOTO TAIICHI (Chiba Inst. of Technol., Fac. of Eng.) SHIRAKURA HIROMI (Chiba Inst. of Technol., Fac. of Eng.) OTSUKI TAKASHI (Univ. of Tokyo, Grad. Sch.) TAKASU AKITSUGU (Univ. of Tokyo, Grad. Sch.) WATANABE KIMITSUNA (Univ. of Tokyo, Grad. Sch.) KOMIYAMA MAKOTO (Univ. of Tokyo, RCAST Res. Center for Adv. Sci. and Technol.) LIANG X (Univ. of Tokyo, RCAST Res. Center for Adv. Sci. and Technol.)

Journal Title;Abstracts. Symposium on Biofunctional Chemistry

Journal Code:L0836A

ISSN:

VOL.15th;NO.;PAGE.12-13(2000)

Figure&Table&Reference;FIG.1, REF.4

Pub. Country;Japan

Language;Japanese

Abstract;We have already succeeded in the synthesis of photo-responsive DNA carrying an azobenzene in the side chain. By using this DNA, duplex formation and dissociation was successfully photo-regulated by the trans-cis isomerization of the incorporated azobenzene. In the present paper, position of azobenzene residue in the sequence was optimized for still more effective photo-regulation. (author abst.)

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