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Accession number;01A0228955
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| Title;Base Selective Recognition and Controlling Gene Expression by Zinc(II) Macrocyclic Polyamine Complexes. |
| Author;
KIKUTA EMIKO
(Hiroshima Univ., Sch. of Med.)
KIMURA EIICHI
(Hiroshima Univ., Sch. of Med.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.15th;NO.;PAGE.26-27(2000)
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| Figure&Table&Reference;FIG.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Zn2+-cyclen complexes selectively recognize thymine(T) nucleotide in aqueous solution at physiological pH, and its aromatic-pendant derivatives selectively bind to T in double-stranded DNA. They selectively bind to TATA box, in promoter region of eukaryotic RNA polymerase II genes, and inhibits the transcriptional factor, TATA binding protein. These T-recognizing Zn2+-cyclen complexes are a new type of small molecular "genetic tanscriptional controlling factor". (author abst.) |
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