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Disposition of Structure-dependent Insulinomimetic Vanadyl Complexes in Rats as Studies by Metallokinetic Analysis using BCM-ESR Method.

Accession number;01A0228966

Title;Disposition of Structure-dependent Insulinomimetic Vanadyl Complexes in Rats as Studies by Metallokinetic Analysis using BCM-ESR Method.

Author; YASUI HIROYUKI (Kyoto Pharm. Univ.) TAMURA ASUKA (Kyoto Pharm. Univ.) TAKINO TOSHIKAZU (Kyoto Pharm. Univ.) SAKURAI HIROMU (Kyoto Pharm. Univ.)

Journal Title;Abstracts. Symposium on Biofunctional Chemistry

Journal Code:L0836A

ISSN:

VOL.15th;NO.;PAGE.50-51(2000)

Figure&Table&Reference;FIG.2

Pub. Country;Japan

Language;Japanese

Abstract;Blood circulation monitoring (BCM)-ESR method to analyze the ESR signals due to paramagnetic species in real time was applied to know the disposition of vanadyl species in the blood of rats, which were given insulinomimetic vanadyl complexes such as bis(picolinato)oxovanadium (VO(PA)2) and its derivative complexes. The results indicated that vanadyl species were considerably distributed to peripheral tissues and gradually eliminated from the circulating blood, depending on their chemical structures. (author abst.)

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