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Accession number;01A0228979
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| Title;Synthesis and characterization of porphyrins bearing diazole rings (VI). Interaction of metal complexes of bisimidazoliumporphyrin with DNA. |
| Author;
YAMAMOTO TOMOKO
(Keio Univ., Fac. of Sci. and Technol.)
YOSHIOKA NAOKI
(Keio Univ., Fac. of Sci. and Technol.)
INOUE HIDENARI
(Keio Univ., Fac. of Sci. and Technol.)
TJAHJONO D H
(Keio Univ., Fac. of Sci. and Technol.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.15th;NO.;PAGE.76-77(2000)
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| Figure&Table&Reference;FIG.2, TBL.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The interaction of metal complexes of bisimidazoliumporphyrin(Zn-1, Cu-1) with DNA was examined by Vis, induced CD and MCD spectroscopies and viscometric measurements. Binding of Zn-1 or Cu-1 to DNA is entoropically driven while that of H2-1 is enthalpically driven. Furthermore they interact to poly(dAdT)2 as strongly as CT-DNA and poly(dGdC)2, suggesting that not only Zn-1 but also Cu-1 interacts selectively with the A-T base pairs of DNA. (author abst.) |
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