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Accession number;01A0228982
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| Title;Relationship between radical species and sphingolipids in apoptosis of HL-60 cells. |
| Author;
YAMADA YASUKO
(Nara Women's Univ.)
KAJIWARA KAZUMI
(Nara Women's Univ.)
TOKUMARU SADAKO
(Joetsu Univ. of Educ.)
MASUZAWA YASUO
(Hyogo Univ. of Teach. Educ.)
KISHIDA ETSU
(Hyogo Univ. of Teach. Educ.)
YANO MIDORI
(Hyogo Univ. of Teach. Educ.)
KOJO SHOSUKE
(Nara Women's Univ.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.15th;NO.;PAGE.82-83(2000)
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| Figure&Table&Reference;FIG.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Effects of three kinds of antagonists against reactive oxygen species were evaluated at the same time in chemically induced apoptosis of human leukemic HL-60 cells. Apoptosis of HL-60 cells induced by actinomycin D and daunorubicin was significantly inhibited by radical scavengers. Caspase-3-like protease activity was increased in cells treated with actinomycin D or daunorubicin. Among ceramides, C16:0 was most abundant. the concentration of C16:0 ceramide increased after the addition of actinomycin D or daunorubicin. This increase in the ceramide was inhibited by antioxidants, indicating that the generation of ROS preceded that of ceramide generation. (author abst.) |
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