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Accession number;01A0228985
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| Title;Interaction of HIV Rev peptides combining PNAs with RRE RNA. |
| Author;
KUMAGAI ICHIRO
(Tokyo Inst. of Technology, Graduate School)
TAKAHASHI TSUYOSHI
(Tokyo Inst. of Technology, Graduate School)
HAMASAKI KEITA
(Tokyo Inst. of Technology, Graduate School)
UENO AKIHIKO
(Tokyo Inst. of Technology, Graduate School)
MIHARA HISAKAZU
(Tokyo Inst. of Technology, Graduate School)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.15th;NO.;PAGE.88-89(2000)
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| Figure&Table&Reference;FIG.2, TBL.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We have attempted to design and synthesize the peptides conjugated with peptide nucleic acids (PNA) in order to create a new functional molecule. In this study, the peptides containing PNA were designed from the sequence of a human immunodeficiency virus type-1 (HIV-1) Rev peptide that can bind the stem-loop IIB of the Rev response element (RRE) RNA. Dissociation constants between the PNA-peptides and RRE were determined by the competition assay using fluorescence anisotropy of Rhod-Rev. (author abst.) |
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