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Accession number;01A0228986
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| Title;Artificial DNAs Forming Double Strands by Metal Complexation. |
| Author;
TANAKA KENTARO
(Univ. of Tokyo, Grad. Sch.)
TASAKA MOTOYUKI
(Graduate Univ. Advances Studies)
HATANO AKIHIKO
(Graduate Univ. Advances Studies)
CHIBA JUN'YA
(Univ. of Tokyo, Grad. Sch.)
SHIRO MOTOO
(Rigaku Corp.)
SHIONOYA MITSUHIKO
(Univ. of Tokyo, Grad. Sch.)
CAO H
(Graduate Univ. Advances Studies)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.15th;NO.;PAGE.90-91(2000)
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| Figure&Table&Reference;FIG.4, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In this paper, we report novel approaches to reconstruct DNAs as functionalized molecules by means of metal complexation. First, novel artificial .BETA.-C-nucleosides bearing a chelator nucleobase have been synthesized. These artificial nucleobases were introduced to oligonucleotides for alternative base pairing through metal coordination instead of the hydrogen bonding in natural DNA. Secondly, a chelator-type adenine mimic, which has two metal binding sites, was synthesized. Its single-stranded ZnII coordination polymer interacted with a DNA oligomer, dT70 and showed the temperature-dependent hyperchromic effect. (author abst.) |
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