Increase of liver GLUT2 protein content in TSOD (Tsumura, Suzuki, Obese Diabetes) mouse, a new genetic animal model of type 2 diabetes.
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Accession number;02A0089743
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| Title;Increase of liver GLUT2 protein content in TSOD (Tsumura, Suzuki, Obese Diabetes) mouse, a new genetic animal model of type 2 diabetes. |
| Author;
MIURA T
(Suzuka Univ. Medical Sci., Mie, Jpn)
KATO M
(Suzuka Univ. Medical Sci., Mie, Jpn)
IWAMOTO N
(Suzuka Univ. Medical Sci., Mie, Jpn)
SUZUKI W
(Tsumura And Co., Ibaraki)
ISHIDA T
(Suzuka Univ. Medical Sci., Mie, Jpn)
TANIGAWA K
(Suzuka Univ. Medical Sci., Mie, Jpn)
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Journal Title;Biomed Res
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Journal Code:Z0236B
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ISSN:0388-6107
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VOL.22;NO.3;PAGE.175-177(2001)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;In order to elucidate the mechanism of hyperglycemia in TSOD (Tsumura, Suzuki, Obese Diabetes) mouse, a new genetic animal model of type 2 diabetes, we examined the alteration of GLUT2 protein content in liver. The liver type glucose transporter (GLUT2) protein content from mouse liver significantly increased in the TSOD mice when compared to that in normal, Tsumura, Suzuki, Non Obesity (TSNO) mice (P<0.01). The TSOD mouse exhibited a significantly increased blood glucose and serum insulin levels when compared with TSNO mouse. These results suggest that the hyperglycemia of TSOD mouse may be due, at least in part, to the increase of GLUT2 protein. (author abst.) |
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