Inclusion Complexes Between Cyclodextrins and Polyaza-macrocycles of Lanthanide(III) Ions. Calorimetric, Molecular Modelling and NMR Studies.
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Accession number;01A0903153
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| Title;Inclusion Complexes Between Cyclodextrins and Polyaza-macrocycles of Lanthanide(III) Ions. Calorimetric, Molecular Modelling and NMR Studies. |
| Author;
BASTOS M
(Univ. Porto, Porto, Prt)
HENRIQUES E S
(Univ. Porto, Porto, Prt)
RAMOS M J
(Univ. Porto, Porto, Prt)
GERALDES C F G C
(Univ. Porto, Porto, Prt)
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Journal Title;Netsu Sokutei Toronkai Koen Yoshishu
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Journal Code:F0840B
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ISSN:
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VOL.36th;NO.;PAGE.32-33(2000)
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| Figure&Table&Reference;TBL.3 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Magnetic Resonance Imaging(MRI) is a recent powerful diagnostic tool in clinical practice. The image is mainly due to the NMRsignal of water protons and, as in other tomographies, it is often necessary to increase its sensitivity and tissue specificity. Paramagnetic lanthanide chelates catalyse the relaxation of water protons in living tissue and, even though they have been used successfully for this purpose, strategies to improve them are in demand. Lanthanide polyazamacrocyclic chelates might form inclusion complexes with cyclodextrins, thus possibly providing an alternative mechanism whereby the solvent proton relaxation rates and the biodistribution of these shift agents could bealtered in vivo. This work reports studies where Calorimetric and Spectroscopic Methods (NMR), as well as Molecular Mechanics Calculations and Molecular Dynamics Simulations were used to study this type of inclusion complexes. Results will be presented for lanthanide complexes of DOTP(1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetrakis(Methylenephosphonate)) and DOTA(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) with different lanthanide ions. (author abst.) |
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