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Accession number;01A0903154
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| Title;Use of Isothermal Microcalorimetry to Characterise Dry Powder Inhalation Formulations: Case Studies. |
| Author;
BRIGGNER L-E
(Astrazeneca R&d Lund, Lund, Swe)
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Journal Title;Netsu Sokutei Toronkai Koen Yoshishu
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Journal Code:F0840B
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ISSN:
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VOL.36th;NO.;PAGE.34-35(2000)
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| Figure&Table&Reference;FIG.2 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Isothermal microcalorimetry has become an almost indispensable tool in the development of new inhalation formulations. The versatility of the technique enables characterisation of almost any physical or chemical process taking place. This lecture will present a few case studies where microcalorimetry has provided major contributions to the understanding and control of physico-chemical solid state phenomena. In dry powder formulations, humidity is obviously of great interest and it is crucial to beable to understand and possibly control the interaction between vapour and powder. Different ways of manufacturing or processing might completely alter physicochemical surface properties like water sorption. The microcalorimetrical approach has proven tobe most useful in the characterisation of interaction with water. Another field of interest is the structural properties obtained in manufacturing steps. Understanding of the influence of different parameters in processes like spray drying or freeze-drying is of utmost importance in pharmaceutical production. Microcalorimetrical techniques have become a valuable tool in the interpretation and controlling of such processes. (author abst.) |
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