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Accession number;01A0903155
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| Title;Isothermal Microcalorimetry in Pharmaceutical Sciences: Overview and Prospects. |
| Author;
WADSOE I
(Lund Univ., Swe)
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Journal Title;Netsu Sokutei Toronkai Koen Yoshishu
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Journal Code:F0840B
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ISSN:
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VOL.36th;NO.;PAGE.36(2000)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;English |
| Abstract;Isothermal microcalorimetry is used for the assessment of non-stability of pharmaceutical compounds. Investigations include measurements of degradation processes, phase transitions and measurements of vapour sorption and dissolution processes. The thermodynamic characterisation of drug-biopolymer binding reactions by titration microcalorimetry is important in the development of new drugs. Isothermal microcalorimetric techniques are well adapted for studies of living cellular systems, but the pharmaceutical industry is not using such methods in their studies of cell-drug interactions. The non-specific nature of heat measurements makes it difficult to interpret results from complex reaction systems. Promising progress has been made in the use of microcalorimetric vessels equipped with specific analytical sensors. (author abst.) |
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