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Accession number;01A1010587
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| Title;Evaluation of Sympathetic Nerve Dysfunction in Cases of Heart Failure Using 123I-Metaiodobenzylguanidine. |
| Author;
YAMAZAKI JUN'ICHI
(Tohodai I Naikagakudai1)
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Journal Title;Journal of the Medical Society of Toho University
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Journal Code:G0654A
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ISSN:0040-8670
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VOL.48;NO.4/5;PAGE.305-309(2001)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Patients with heart failure have a reduced number of sympathetic nerves, decreased myocardial norepinephrine (NE) levels, accelerated NE turnover, and NE re-uptake disorder at sympathetic nerve endings. 123I-metaiodobenzylguanidine (MIBG), an NE analogue, is taken into the cardiac sympathetic nerve endings in a manner similar to NE and is gradually washed out. We performed this study to determine which parameters of MIBG imaging are accurate predictors of response to beta-blocker therapy and to evaluate differences in therapeutic effects among various beta-blockers in patients with heart failure. LVEF significantly correlated with extent score (ES), severity score (SS) and washout rate (WR) in MIBG images. After beta-blocker therapy, LVEF significantly improved from 36% to 55% after 6 months in the improved group, and WR significantly improved from 51% to 35% then to 33%. These findings suggest that MIBG is useful in examining the severity of DCM and determining the therapeutic utility of beta-blocker therapy. (author abst.) |
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