The Effects of Ulinastatin on Acute Gastrointestinal Lesions Induced by Platelet Activating Factor and the Changes in Leukotrien B4 in Dogs.
|
Accession number;01A1010589
|
| Title;The Effects of Ulinastatin on Acute Gastrointestinal Lesions Induced by Platelet Activating Factor and the Changes in Leukotrien B4 in Dogs. |
| Author;
HARA AKIO
(Tohodai I Sakurabyoin Geka)
|
Journal Title;Journal of the Medical Society of Toho University
|
Journal Code:G0654A
|
ISSN:0040-8670
|
|
VOL.48;NO.4/5;PAGE.321-330(2001)
|
| Figure&Table&Reference;FIG.10, REF.43 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Platelet activating factor (PAF) was administered to dogs to induce acute lesions on the mucosa of the digestive tract. These lesions were used as indices to evaluate the effects of concomitant administration of ulinastatin (UTI). The dogs were classified into two groups according to respective drug treatment and a comparative examination was conducted. One group of dogs was given only intravenous PAF (untreated group) and a second group received intravenous UTI 30 minutes before, and during PAF administration (treated group). The untreated group experienced reductions in blood pressure, stomach and liver blood flow, white blood cell count, platelet count, antithrombin III (AT-III) and .ALPHA.2-plasmin inhibitor (.ALPHA.2-PI) and an increase in leukotrien B4 (LTB4). Acute lesions, i.e., rubefaction, hemorrhage, and erosion, were observed on the mucosa of the digestive tract. The UTI treatment group, however, experienced less reduction in blood pressure and stomach blood flow, in addition to the inhibition of the LTB4 increase and less severe acute lesions on the mucosa of the digestive tract. These results suggest that UTI is useful in preventing and treating postoperative acute organ disorder. (author abst.) |
|
|
|
Related Articles;
|
|
