The Effect of Diesel Exhaust on Ventilatory Capacity in Rats.
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Accession number;01A1010590
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| Title;The Effect of Diesel Exhaust on Ventilatory Capacity in Rats. |
| Author;
SANNO KEN
(Tohodai I Naikagakudai4)
OSAWA MASANOBU
(Tokyo Metrop. Res. Lab. of Public Health)
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Journal Title;Journal of the Medical Society of Toho University
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Journal Code:G0654A
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ISSN:0040-8670
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VOL.48;NO.4/5;PAGE.331-338(2001)
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| Figure&Table&Reference;FIG.4, TBL.3, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Exposure to diesel engine exhaust gasses and particles (DEP), common air pollutants, is known to cause pulmonary dysfunction. The present study was designed to elucidate the effects of such exposure on ventilatory variables-oxygen uptake (VO2), and lung diffusion capacity for carbon monoxide (DLCO)-in Fisher rats (F344/DuCrj). One hundred and two rats were divided into 3 groups: 1) the total diesel exhaust group (H), 2) the exhaust without particles group (ND), and 3) control group (C). Rats were exposed to the gasses for 3 and 6 months. At 3 or 6 months exposure, DLCO significantly decreased in only group H rats. At 6 months VO2 decreased in group H rats. At 3 and 6 months exposure, positive correlations were noted between DLCO and VO2 in all groups. These results indicate that DEP, rather than NO2 gasses, contribute to decrease DLCO and VO2. (author abst.) |
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