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Accession number;01A1010591
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| Title;The Effect of Hormone Replacement Therapy on Blood Coagulation and Fibrinolysis. |
| Author;
FUSE YOJI
(Teikyodai I Mizonokuchibyoin Sanfujinka)
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Journal Title;Journal of the Medical Society of Toho University
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Journal Code:G0654A
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ISSN:0040-8670
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VOL.48;NO.4/5;PAGE.339-346(2001)
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| Figure&Table&Reference;FIG.7, TBL.1, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The effect of hormone replacement therapy (HRT) on blood coagulation and fibrinolysis was evaluated in 34 postmenopausal women. Prothrombin activity increased and activated partial thromboplastin time decreased with HRT. Both fibrinogen and plasminogen significantly increased. Antithrombin III activity significantly decreased. In particular, blood coagulation factor VII, IX and X activities increased, but changes in .ALPHA.2-Plasmin inhibitor and protein C were not noted. The effect of HRT on blood platelet function was significant. Platelet count and platelet aggregation increased. There was a conspicuous increase in ADP aggregation. Both .BETA.-thromboglobulin and blood platelet factor 4 significantly increased. These findings suggest that examination of blood coagulation and fibrinolysis should be performed during HRT and that HRT should be promptly discontinued if a hypercoagulable state is observed. (author abst.) |
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